Tribulus terrestris saponins are non-hormonal supplements because this herb does not contain any of the three main hormones (estrogen, progesterone, and testosterone). In addition, it also has the effect of lowering blood pressure and blood lipids, which contain the peroxide decomposing enzyme, which has an obvious anti-aging effect. There are also beauty effects, long-term use can remove facial scars, and make skin soft and smooth.
Tribulus terrestris L. is a genus of Tribulus terrestris in the family Tribulus Terrestris. It is an annual herb, usually born on barren hills, fields, and roadsides. It is distributed throughout the country, most commonly in the north of the Yangtze River. This plant is traditional Chinese medicine, with the effects of promoting blood and dispelling wind, calming the liver and relieving depression, brightening eyes, and relieving itching, used to treat headache, dizziness, red eyes and tears, bronchitis, hypertension, skin itching, rubella, and other diseases.
The active constituents of Tribulus terrestris consist of alkaloids. At present, 3 kinds of alkaloids have been isolated, namely, Harman, Harmin, and Harol. Flavonoids, the flavonoid aglycones are mainly quercetin, kaempferol, and isorhamnetin; They also contain saponins. The main active components of Tribulus tribulus are trillioside, dioscorean, dioscorea, dioscorea, protodioscorea, protodioscorea, Tribullosin, neohacogenin and Tribulosin, dioscorea genin, Roscogenin, Greensin genin, 3-deoxydioscorea genin, hacogenin, etc. Others contain sterols, including β-sitosterol, stigmasterol, and canola sterol. The roots of Tribulus terrestris contain 22 kinds of free amino acids.
Others contain anthraquinones, sugars, fatty acids, and vitamins. Tribulus Terrestris and its active components can prevent the occurrence and development of thrombosis in the small artery system, improve the immunity of the body, and improve the ability to scavenge oxygen free radicals. For patients with cerebrovascular disorders, it can reduce complications, reduce the rate of disability, shorten the rehabilitation period, and no adverse reactions. At present, the study of Tribulus terrestris and its active component in the treatment of cardiovascular and cerebrovascular diseases mainly focuses on its active component.
Tribulus terrestris saponins Apply
Anti-atherosclerosis
The application of Tribusaponin can prevent and treat arteriosclerosis, and can significantly improve the patient’s symptoms, which is better than the known anti-arteriosclerosis drugs.
Treatment of angina pectoris of coronary heart disease
Three-dimensional echocardiography was used to examine the changes in left ventricular systolic function in patients with angina pectoris of coronary heart disease before and after taking Yintribuus capsule (a compound preparation of ginkgo biloba and Tribulus terrestris). The total effective rate was 85.7%, and the left ventricular ejection fraction was increased, including both early and late systolic ejection numbers, and the range of left ventricular segment systolic rate <5% was significantly reduced. It showed that this drug can improve myocardial ischemia and improve the early and late systolic function of the left ventricle.
Clinical observation has proved that Xinnaoshutong (Tribulus tribulus saponin preparation) can dilate coronary artery, improve coronary circulation, improve hypoxia tolerance, prevent ischemic ECG changes induced by posterior pituitary and isoproterenol, and inhibit platelet aggregation. It can also increase HDL, reduce plasma specific viscosity, promote the running speed of red blood cells in plasma, dreg microcirculation, and then restore abnormal ECG, reduce coronary heart disease angina pectoris and chest tightness, and other symptoms.
Treatment of cerebrovascular disorders
Abnormal hemorheology is one of the causes of insufficient cerebral blood supply and hypoxia and is a comprehensive index reflecting the functional and structural changes of blood, blood vessels, and heart. 30 cases of cerebral thrombosis were treated with Xinnaoxutong (Tribulus Tribulus saponin preparation) tablets, Tid, 3 tablets/day, 4 weeks as a course of treatment. After treatment, the total cholesterol and HDL-C were decreased significantly, and the hemorheological indexes were improved, among which the whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity were decreased significantly. After 7 months of clinical verification, the total effective rate was 93.33%.
Forty patients with cerebral arteriosclerosis and cerebral infarction were treated with 912-II tablets (made of active constituents of Tribulus teristus saponins), 45mg, Tid each time, for 12 weeks. After treatment, serum TG and HDL decreased significantly, as well as whole blood specific viscosity, fibrinogen Fg, hematopoietic PCV, and platelet aggregation rate also decreased significantly. At the same time, headache, dizziness, chest tightness, chest pain, palpitation, and other symptoms were also significantly improved. The results showed that 912-II tablet could improve hemorheology, regulate platelet function, anti-thrombosis, relieve microcirculation disorders, and significantly relieve clinical symptoms of patients with cerebrovascular disorders.
Treatment of acute stage of pulmonary heart disease
Whole blood-specific viscosity, plasma-specific viscosity, hematocrit HCT, ESR, and erythrocyte accumulation index were determined by a capillary viscometer. Xinnaoxutong (Tribulus tribulus saponin preparation) 30mg, tid, 7-10d later, all indexes were improved, but the whole blood specific viscosity and accumulation index decreased more obviously. Partial thromboplastin time and thrombin time were significantly prolonged, and Fg was significantly decreased.
The reaction time, coagulation time, and maximum clotting time of the thrombus were significantly prolonged by the thrombus elastometer. It can be seen that Xinnaoshutong (Tribulus Terrestris saponin preparation) can significantly reduce blood viscosity, change blood rheology, reduce the activity of endogenous coagulation factors, and improve the anticoagulation ability, and prevent the occurrence and development of hypercoagulability of pulmonary heart disease to a certain extent. The clinical application also showed that the drug had rapid effects, obvious effects, and no obvious side effects.
Treatment of high blood pressure
901 tablets (made of Tribulus tribulus saponins) were administered to 30 hypertensive patients with 100mg, Tid, for 2 months. After treatment, whole blood viscosity, plasma specific viscosity, hematocrit, fibrinogen, platelet aggregation function, and blood triglyceride were significantly decreased, and clinical symptoms were also significantly improved. It is proved that 901 tablets can improve the symptoms of blood stasis, improve the hemorheology of patients, and can be used as a therapeutic drug for hypertension, and have a potential role in preventing and treating stroke.
Enhance sexual function and anti-aging
Tribestan is used to increase sperm count and motility in men, enhance ovarian function in women, treat sexual deficiency and infertility, and prevent menopausal syndrome. The clinical trial of Xinnaoshutong (Tribulus terrestris saponin preparation) was used to treat 38 cases of male sexual dysfunction, the effective rate was 85.7%. Tribulus terrestris extract can be used as a hormone-free energy supplement for athletes
Tribulus terrestris saponins preparation
Method 1:
Preparation of Tribulus terrestris extract, which includes the following steps:
- Take raw Tribulus Terrestris fruit, extract it with 10% ~ 90% ethanol, filter the extract, cool the filtrate, and place it for about 10 ~ 12 hours to remove the mucous, take the supernatant after high-speed centrifugation, recover the ethanol, concentrate it into dry extract, dissolve it into solution with water, and then pass through the macroporous adsorption resin column;
- After loading the column, wash with water until colorless, then wash with 10% ~ 30% ethanol until colorless, and then eluted with 50% ~ 95% ethanol, collect the eluent, recover the ethanol until no alcohol taste, that is, Tribulus terrestris extract.
Method 2:
A method for preparing Tribulus terrestris extract with Tribulus terrestris saponins as the main component, including the following steps:
1) Take the raw materials of Tribulus tribulus, boil them in water for 0.5-2 hours, add vinegar to the water, bury them for 1-4 hours after cooking, and cool them naturally;
2) Add 5-8 times ethyl acetate to the soaked raw material, extract for 1-2 hours, filter to obtain the extraction solution;
3) The extraction solution was extracted, the pH was adjusted to neutral, concentrated under reduced pressure, and separated by polyamide chromatography column. The ratio of loading volume to polyamide was 1:5-1 ∶25, and the ratio of diameter to height of resin column was 1:4-1 ∶15. The impurities were eluted with 1-10 times column water and 5-10 times column volume 20%-40% ethanol solution, respectively. Then elution with 4-12 times the column volume of 40%-90% ethanol solution, collect 40%-90% ethanol wash solution, recover ethanol under pressure, and concentrate;
4) Adjust the pH to 4.0-6.0, extract 1-8 times the amount of tert-butylmethyl ether in solution, separate the organic layer by 2-6 times, recover the tert-butylmethyl ether under pressure, add 1-3 times the amount of silica gel, stir, and dry;
5) The stirred silica gel was added to the packed dry silica gel column with a diameter-to-height ratio of 1:4-1 ∶ 15. The eluent of 50% ethanol-tert-butyl methyl ether (4:6) to (6:4) was collected by gradient elution using 50% ethanol-tert-butyl methyl ether as eluent.
6) The eluent in the eluent is recovered under pressure to obtain the crude product;
7) Add 5-20 times 50% ethanol solution to dissolve, microwave vacuum drying, the product.
